Prognostic Significance of Apoptosis Regulators in B-Cell Chronic Lymphocytic Leukemia
نویسندگان
چکیده
منابع مشابه
Prognostic significance of the cell cycle inhibitor p27Kip1 in chronic B-cell lymphocytic leukemia.
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of resting lymphocytes. The identification of p27(kip1), a cyclin-dependent kinase inhibitor that contributes to cell cycle arrest and represents a link between extracellular signals and cell cycle, prompted us to study p27 protein in the lymphocytes from 88 patients with B-CLL and 32 patients with other chronic B-...
متن کامل[Apoptosis in pathogenesis of B-cell chronic lymphocytic leukemia].
B-cell chronic lymphocytic leukemia (B-CLL), a clonal expansion of B CD5+ cells, is the most frequent type of adult leukemia in western countries. Accumulation of neoplastic B-cells is caused not by their higher proliferation rate, but by their prolonged life-span due to dysregulation of apoptosis. Many proteins act as inducers or inhibitors in controlling apoptosis. A high level of antiapoptot...
متن کاملPrognostic significance of immunoglobulin phenotype in B cell chronic lymphocytic leukemia.
Seventy-six consecutive untreated patients with B cell chronic lymphocytic leukemia (B-CLL) and classified according to Binet's staging system were studied at the clinical presentation. Several immunologic parameters (number of total and T circulating lymphocytes and their surface membrane immunoglobulin [Smlg] phenotypes and levels of serum Ig) were evaluated with the aim of identifying a biol...
متن کاملB-cell Chronic Lymphocytic Leukemia
Purpose: To review the recent major advances in the molecular and cell biology of B-cell chronic lymphocytic leukemia (B-CLL). Methods: Weanalyzed thenatureofmalignantB-CLLB cells and their interactions with the microenvironment. Results: B-CLL is a malignancy of a mantle zonebased subpopulation of anergic, self-reactive, activated CD51 B cells devoted to the production of polyreactive natural ...
متن کامل[Prognostic significance of serum immunoglobulins in chronic lymphocytic leukemia].
-CLL is frequently accompanied by decreased levels of serum immunoglobulins which increases patients susceptibility to infections (1,2). Low levels of IgA, IgM and IgG occur in 30%, 30% and 10% of B-CLL patients respectively at the time of diagnosis. The appearance of decreased levels of immunoglobulins is a continuos process developing spontaneously during the untreated course of the disease. ...
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ژورنال
عنوان ژورنال: Journal of Cancer Therapy
سال: 2017
ISSN: 2151-1934,2151-1942
DOI: 10.4236/jct.2017.84032